A new study led by Harvard T.H. Chan School of Public Health (HSPH) researchers identifies a key molecular mechanism behind the health benefits of dietary restriction, or reduced food intake without malnutrition. Also known as calorie restriction, dietary restriction is best known for its ability to slow aging in laboratory animals.The findings show that restricting two amino acids, methionine and cysteine, results in increased production of hydrogen sulfide (H2S) and protection against ischemia-reperfusion injury — the damage to tissue that occurs following the interruption of blood flow, such as during organ transplants and stroke. Increased H2S production upon dietary restriction was also associated with lifespan extension in worms, flies, and yeast.Although H2S gas is extremely toxic in high amounts, low levels present in naturally occurring sulfur springs have long been associated with health benefits. Mammalian cells also produce low levels of H2S, but this is the first time that this molecule has been linked directly to the health benefits of dietary restriction.“This finding suggests that H2S is one of the key molecules responsible for the benefits of dietary restriction in mammals and lower organisms as well,” said senior author James Mitchell, associate professor of genetics and complex diseases. “While more experiments are required to understand how H2S exerts its beneficial effects, it does give us a new perspective on which molecular players to target therapeutically in our efforts to combat human disease and aging.”The study appears online today in Cell.Dietary restriction is a type of intervention that can include reduced overall food intake, decreased consumption of particular macronutrients such as protein, or intermittent bouts of fasting. It is known to have beneficial health effects, including protection from tissue injury and improved metabolism. It has also been shown to extend the lifespan of multiple model organisms, ranging from yeast to primates. The molecular explanations for these effects are not completely understood, but were thought to require protective antioxidant responses activated by the mild oxidative stress caused by dietary restriction itself.First author Christopher Hine, research fellow in the Department of Genetics and Complex Diseases, and colleagues demonstrated that one week of dietary restriction increased antioxidant responses and protected mice from liver ischemia-reperfusion injury, but surprisingly, this protective effect was intact even in animals that could not mount such an antioxidant response. Instead, the researchers found that the protection required increased production of H2S, which occurred upon reduction of dietary intake of methionine and cysteine. When the diet was supplemented with these two amino acids, increased H2S production and dietary restriction benefits were both lost.The investigators also found that genes involved in H2S production were also required for longevity benefits of dietary restriction in other organisms.“These findings give us a better understanding of how dietary interventions extend lifespan and protect against injury. More immediately, they could have important implications for what to eat and not to eat before a planned acute stress like surgery, when the risk of ischemic injury can be relatively high,” said Hine.Other Harvard T.H. Chan School of Public Health authors include Eylul Harputlugil, Lear Brace, Humberto Trevino Villarreal, Pedro Mejia, Yue Zhang, and William Mair.
LONDON, England (CMC) – Any hopes West Indies harboured of overhauling Pakistan and clinching the crucial eighth spot in the International Cricket Council (ICC) one-day rankings have all but disappeared as the Asian side have surged to sixth position following their capture of the ICC Champions Trophy here Sunday.In the latest rankings released yesterday by cricket’s world governing body, Pakistan gained four points to jump from eighth to sixth on 95 points, now ahead of seventh-placed Bangladesh on 94 and Sri Lanka, who have slipped to eighth on 93 points.Pakistan, who had lingered at eighth in the world rankings in recent times, convincingly beat powerhouse India in the final at the Oval by 180 runs to lift the title regarded as the mini World Cup.With the success, Pakistan have further enhanced their chances of automatic qualification for the 2019 World Cup in England while West Indies slipped further behind in their quest to also seal a direct spot at the tournament.Ironically, Pakistan had edged West Indies for the final spot in the Champions Trophy because of their eighth place ranking.West Indies remain in ninth spot on 77 points in the latest rankings following a disappointing 1-1 draw in the recent three-match series against ICC Associate side Afghanistan.They are now faced with the task of closing a 16-point gap on Sri Lanka by the September 30 cut-off date for automatic qualification for the World Cup. Hosts England and the remaining top seven sides in the rankings by that date will earn automatic qualification.The Windies face India in a five-match series starting Friday at Queen’s Park Oval in Trinidad and take on fourth-ranked England in another five-match series in September.If they lose these series and subsequently fail to qualify automatically, the Caribbean side will enter a 10-team qualifier scheduled for next year, to determine the final two World Cup berths.South Africa have retained top spot in the newest rankings on 119 points, two ratings points ahead of Australia with India lying one point back in third.Latest ICC One-Day International rankings:1. South Africa 1192. Australia 1173. India 116 (-1)4. England 113 (-1)5. New Zealand 1116. Pakistan 95 (+4)7. Bangladesh 94 (-1)8. Sri Lanka 939. West Indies 7710. Afghanistan 5411. Zimbabwe 4612. Ireland 41
Troy Daniels says he received calls from both Rob Pelinka and Anthony Davis about coming to LAL, picking them over interest from GSW and OKC. It helped, he thinks, that he once poured in 29 pts in a double OT win (including a game tying 3 in OT) over NOP when he played for MEM— Dave McMenamin (@mcten) July 15, 2019“I love being on those type platforms, hitting game-winners in the playoffs and those atmospheres and stuff like that,” Daniels said, via the Southern California News Group. “It’s just unbelievable. And as a player in the NBA, you want to be in those situations. It’s one thing to be in the NBA, it’s another thing to actually play for a championship and I’m just fortunate enough to be on this team.”The Lakers revamped their roster this offseason when they acquired Davis in a trade with the Pelicans to pair with LeBron James. Daniels, a career 40% 3-point shooter, said he’s excited to play with the two stars. Related News The Lakers wanted Troy Daniels.The 28-year-old guard told reporters he received calls from Los Angeles general manager Rob Pelinka and Anthony Davis while he was a free agent this summer. He went on to sign a one-year, $2.1 million contract with the team. NBA 2019-20 win-total projections: Bucks, Clippers lead the way Anthony Davis and LeBron James’ input ‘incredibly valuable’ in building Lakers roster, GM says “I think it makes it a lot easier for me as well as them because they have somebody to kick it out to and know nine times out of 10 it is probably going to go in if he is open,” Daniels said. “For me, I’m not trying to get open, I am probably going to be open, because they are going to command a lot of double-teams and a lot of attention.”The Lakers created cap space to add a third max player but missed out on Kawhi Leonard, who signed with the Clippers. They then inked Avery Bradley, Danny Green, Kentavious Caldwell-Pope, JaVale McGee, Quinn Cook, DeMarcus Cousins, Rajon Rondo and Alex Caruso. Avery Bradley explains decision to sign with Lakers “I’m going to do whatever this team needs,” Daniels said. “Whatever the organization needs from me, I’m going to be there and I’m going to do it at a high level.”Los Angeles signed veteran wing Jared Dudley earlier this month, as well.
Week 13 College Fantasy Football DFS Picks: WRsBest Start: Ja’Marr Chase, LSU vs. Arkansas ($8,100). Chase has been one of the primary beneficiaries of the Tiger’s new offense, rolling up 1,116 yards and 13 TDs over nine games. A 29-fantasy-point-per-game average and a game against a bad Arkansas defense makes for one of the best Week 13 matchup combos. Chase is primed to get his seventh 100-yard game of the season. Best Value: Easop Winston, Washington State vs. Oregon State ($7,300). Washington State boasts the best passing offense in the country, and Winston is one of QB Aaron Gordon’s primary targets. Through 10 games Winston has turned 70 receptions into 826 yards and 11 TDs. He is coming off a two-game stretch with 20 receptions, 220 yards and two TDs. Winston should be in for another big night as the Cougars face a very bad Oregon State pass defense. Best Sleeper: Chatarius Atwell, Louisville vs. Syracuse ($5,900). Atwell has had a monster season so far for the Cardinals, catching 52 passes for 920 yards and nine TDs. He has scored at least 21 fantasy points in five of the past six games and this week should be no different. Syracuse is currently ranked 94th in the country in pass defense and will have its hands full trying to keep Atwell contained. The sophomore has a great chance to get over 1,000 yards for the season with a big game this weekend. Week 13 College Fantasy Football DFS Picks: QBsBest Start: Jalen Hurts, Oklahoma vs. TCU ($9,000). Hurts has been on of the best DFS quarterbacks this entire season, averaging 44 fantasy points per game and only scoring fewer than 36 fantasy points once. TCU will be a tough matchup, but Hurts is a must-start and should have another big game, making him especially valuable if he’s faded by others because of the matchup. Best Value: Charlie Brewer, Baylor vs. Texas ($7,900). Brewer has been great for DFS players this season, scoring at least 20 points in all but one game. He is coming off a four-TD, 33-fantasy-point performance against Oklahoma, and he should be looking forward to an easier matchup this week with Texas. The Longhorns are ranked 110th in total defense, which will provide Brewer with plenty of opportunities to extended his scoring streak.Best Sleeper: Jordan McCloud, South Florida vs. Memphis ($5,900). McCloud has been solid since taking over for injured starter Blake Barnett and seems to be getting more comfortable. This week the Bulls host the high-scoring Memphis Tigers and will need a big game out of McCloud if they hope to keep pace.MORE: CFBDynasty player rankingsWeek 13 College Fantasy Football DFS Picks: RBsBest Start: Max Borghi, Washington State vs. Oregon State ($8,000). Borghi has been very impressive this season, catching and rushing his way to 1,164 yards and 12 TDs. He should he in for another big game this week as the Cougars play host to Oregon State and their 102nd-ranked defense. Best Value: Joshua Kelley, UCLA at USC ($6,700). Kelley was not able to find much running room in Week 12 against Utah’s top-ranked run defense, managing just 78 yards on 19 carries. However, this week he gets to face a USCdefense allowing more than 167 yards per game on the ground. Look for the Bruins to feed Kelley early and often in this PAC-12 rivalry game.Best Sleeper: Greg McCrae, UCF at Tulane ($5,200). McCrae had been handling a huge chunk of the UCF rushing load before being injured in Week 8. He is expected to return this weekend against Tulane, who are currently allowing 161 rushing yards per game. Even splitting carries, McCrae should be able put up solid numbers in this matchup. Week 13 of college football season is upon us, and it’s going to be a fun one for college fantasy football owners. We are treated to several great matchups, including Penn State vs. Ohio State, Texas vs. Baylor, Washington State vs. Oregon State, and UCLA vs. USC, among many others. With fewer teams on bye this week, there will be plenty of usable players available for DraftKings contests, so be sure to take into consideration the projected totals (over/under) while setting your DFS lineups.Before getting into this week’s picks, just a reminder that if you’re looking for more help setting your season-long or DFS lineups, check out the comprehensive Week 13 college fantasy football rankings at CFBDynasty. Every week, CFBDynasty provides college fantasy football player rankings for each position based on projected fantasy points. Use promo code “sportingnews” to save 25 percent on your membership, which gets you access to all of their exclusive weekly content.WEEK 12 NFL DFS LINEUPS: FD cash | FD GPP | DK cash | DK GPP | Y! cash | Y! GPP