And they have been linked with a move for dynamic midfield threat and former United flop Memphis Depay.His first start – and only goal – came in the 4-0 away thumping of Red Star Belgrade in the Champions League last month.Lo Celso’s only Premier League start came in the 1-1 home draw against Sheffield United on November 9 – Pochettino’s last game in charge.2Pochettino must pay Spurs £12.5m if he takes another Prem job this season amid Arsenal and Man United links GIOVANI LO CELSO is considering quitting Spurs just four months after joining, according to reports.The 23-year-old Argentina midfielder, on loan from Real Betis, signed for Tottenham under fellow countryman Mauricio Pochettino.2 Lo Celso will look move to away from Spurs in January, reports claimCredit: ReutersThings looked promising when he made three appearances from the bench in Spurs’ first four games of the season.But then ex-boss Poch – who will reportedly have to pay his former employer £12.5m if he takes another Prem job this season – found himself under increasing pressure after a barrage of bad results and in no mood to take a chance on new signings.That situation has not improved under recently appointed Jose Mourinho.The Portuguese granted Lo Celso an 88th-minute substitute appearance in last weekend’s 3-2 win over Bournemouth.Now Marca say Lo Celso will look to the market in January for more game time, as it appears it will not be forthcoming under Mourinho.LADBROKES 1-2-FREE Simply predict Man City vs Man Utd, Leicester and Wolves scores this coming weekend and win £100Lo Celso is also keen to keep his place in Lionel Scaloni’s Argentina side.To do so, he knows regular playing time is an absolute must.Manchester United had previously shown interest in the former Paris Saint-Germain star but lost out to Daniel Levy’s negotiating skills.Lo Celso has played a part in just half of Spurs’ games this season, with the club six points off the top four.spurs newsHARRY ALL FOUR ITKane admits Spurs must win EIGHT games to rise into Champions League spotGossipALL GONE PETE TONGVertonghen wanted by host of Italian clubs as long Spurs spell nears endBELOW PARRSpurs suffer blow with Parrott to miss Prem restart after appendix operationPicturedSHIRT STORMNew Spurs 2020/21 home top leaked but angry fans slam silver design as ‘awful”STEP BY STEP’Jose fears for players’ welfare during restart as stars begin ‘pre-season’KAN’T HAVE THATVictor Osimhen keen on Spurs move but only if they sell Kane this summer
The study focused on the 95,500 women whose cancers were invasive rather than still confined to a milk duct. About 39 percent of such tumors in black women were estrogen receptor-negative, or ER-negative, compared with 22 percent of those in white women. Estrogen helps tumors grow. Drugs that block this hormone, like tamoxifen and a class of medications called aromatase inhibitors, work against these cancers. ER-negative tumors are resistant to such therapies and harder to treat. In the study, ER-negative tumors were more common in black women at every stage of disease and at all ages. 160Want local news?Sign up for the Localist and stay informed Something went wrong. Please try again.subscribeCongratulations! You’re all set! The study is the largest yet to link a biological factor to the racial disparity, which has also been blamed on black women getting fewer mammograms and less aggressive treatment. “This puts biology more to the forefront,” said Dr. Julie Gralow, a cancer specialist at the University of Washington School of Medicine familiar with the work. “It’s not just access to care, access to treatment and other factors that have been implicated in the past.” Breast cancer is the most common cancer in American women. An estimated 178,480 new cases and 40,460 deaths from it are expected in the U.S. this year. Blacks are less likely than whites to develop breast cancer but are more likely to die from it, doctors have long known. Blacks are also diagnosed at younger ages and at later stages of disease. Researchers for the first time used the National Cancer Data Base, a tumor registry maintained by the American College of Surgeons, to explore these issues, using more than 170,000 cases diagnosed in 1998. Ten percent were in black women. HEALTH: Research finds standard breast disease treatments often don’t help black women. By Marilynn Marchione THE ASSOCIATED PRESS A new study gives a possible explanation for why breast cancer is more deadly in black women: They are more likely to have tumors that do not respond to the hormone-based treatments that help many others with the disease.